| Immunogen | HighlypurifiedChATobtainedfromporcinebrain(Ostermann-Fatifetal.,1990). | 
| Clone | 1.B3.9B3 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Reactswithcholineacetyltransferase(ChAT)-positivecellsfromhumans,ratsandpigs(Ostermann-Fatifetal.,1992a,b). | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Cholinergicsystemsareimplicatedinnumerousneurologicfunctions.AlterationinsomecholinergicneuronsmayaccountforthedisturbancesofAlzheimerdisease.Theproteinencodedbythisgenesynthesizestheneurotransmitteracetylcholine.Alternativesplicevariantshavebeenfoundthatcontainalternative5"untranslatedexons.Threeofthefourdescribedsplicevariantsencodeidentical69kDaproteinswhileonevariantencodesboththe69kDaandalarger82kDaprotein. | 
| GeneSymbol | CHATChATCMS1A2CHOACTaseCMS1AEC2.3.1.6
 | 
| PurificationMethod | ProteinAPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P28329#CatalyzesthereversIBLesynthesisofacetylcholine(ACh)fromacetylCoAandcholineatcholinergicsynapses. SIZE:748aminoacids;82568Da
 DISEASE:SwissProt:P28329#DefectsinCHATarethecauseoffamilialinfantilemyastheniagravis2(FIMG2)[MIM:254210,254200];alsoknownasCMS-EA.FIMG2patientshavemyasthenicsymptomssincebirthorearlyinfancy,negativetestsforanti-AChRantibodies,andabruptepisodiccriseswithincreasedweakness,bulbarparalysis,andapneaprecipitatedbyundueexertion,fever,orexcitement.Inheritanceisautosomalrecessive.
 SIMILARITY:SwissProt:P28329##Belongstothecarnitine/cholineacetyltransferasefamily.
 | 
| MolecularWeight | 69kDa |