| Immunogen | RaisedagainsttheP19subunitofrecombinanthumanCaspase-2protein. | 
| Clone | 11B4 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rat | 
| Specificity | MAB3507antibodyrecognizesareactiveepitopethatliesintheP19subunitofhumanCaspase-2(ICH-1,Nedd-2). | 
| Isotype | IgG2a | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theproteolyticcleavageofthisproteinisinducedbyavarietyofapoptoticstimuli.Alternativesplicingofthisgeneresultsinmultipletranscriptvariantsthatencodedifferentisoforms. | 
| GeneSymbol | CASP2NEDD2ICH1NEDD-2ICH-1L/1SCASP-2ICH-1LEC3.4.22.55[Contains:Caspase-2subunitp18Caspase-2subunitp13Caspase-2subunitp12].
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| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P42575#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Mightfunctionbyeitheractivatingsomeproteinsrequiredforcelldeathorinactivatingproteinsnecessaryforcellsurvival. SIZE:452aminoacids;50685Da
 SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbyap18subunitandap12subunit.InteractswithLRDD.
 TISSUESPECIFICITY:Expressedinlargeramountsintheembryoniclung,liverandkidneythanintheheartandbrain.Intheadultshigherlevelexpressionisseenintheplacenta,lung,kidney,pancreasthanintheheart,brain,liverandskeletalmuscle.
 PTM:Thematureproteasecanprocessitsownpropeptide,butnotthatofothercaspases.
 SIMILARITY:SwissProt:P42575##BelongstothepeptidaseC14family.&Contains1CARDdomain.
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