| Immunogen | PurifiedbovineDBH. | 
| Clone | 4F10.2 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Mouse | 
| Specificity | Dopaminebetahydroxylase(DBH). | 
| Isotype | IgG1 | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | TheproteinencodedbythisgeneisanoxidoreductasebelongingtothecoppertypeII,ascorbate-dependentmonooxygenasefamily.Itispresentinthesynapticvesiclesofpostganglionicsympatheticneuronsandconvertsdopaminetonorepinephrine.Itexistsinbothsolubleandmembrane-boundforms,dependingontheabsenceorpresence,respectively,ofasignalpeptide. | 
| GeneSymbol | DBHDBMEC1.14.17.1[Contains:Solubledopaminebeta-hydroxylase].
 | 
| PurificationMethod | Unpurified | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P09172#Conversionofdopaminetonoradrenaline. COFACTOR:Binds1PQQpersubunit.&Binds2copperionspersubunit.
 SIZE:617aminoacids;69065Da
 SUBUNIT:Homotetramercomposedoftwonon-covalentlybounddisulfide-linkeddimers.
 SUBCELLULARLOCATION:Solubledopaminebeta-hydroxylase:Cytoplasmicvesicle,secretoryvesiclelumen.Cytoplasmicvesicle,secretoryvesicle,chromaffingranulelumen.&Cytoplasmicvesicle,secretoryvesiclemembrane;Single-passtypeIImembraneprotein.Cytoplasmicvesicle,secretoryvesicle,chromaffingranulemembrane;Single-passtypeIImembraneprotein(Potential).
 DISEASE:SwissProt:P09172#DefectsinDBHarethecauseofDBHdeficiency[MIM:223360];alsocallednorepinephrinedeficiencyornoradrenalinedeficiency.Thisdisorderischaracterizedbyprofounddeficitsinautonomicandcardiovascularfunction,butapparentlyonlysubtlesigns,ifany,ofcentralnervoussystemdysfunction.
 SIMILARITY:SwissProt:P09172##BelongstothecoppertypeIIascorbate-dependentmonooxygenasefamily.&Contains1DOMONdomain.
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