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Millipore/FCMAB120P | Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2/FCMAB120P/100 tests
  • Millipore/FCMAB120P | Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2/FCMAB120P/100 tests

Millipore/FCMAB120P | Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2/FCMAB120P/100 tests

價格: ￥3204.00 市場價: 5340.00
貨號: FCMAB120P
品牌: Millipore
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    • Description
      CatalogueNumberFCMAB120P
      TradeName
      • Milli-Mark
      DescriptionMilli-MarkAnti-Beta-catenin-PEAntibody,clone7F7.2
      AlternateNames
      • BetaCatenin
        Catenin(cadherin-associatedprotein),beta1
      BackgroundInformationCateninsareproteinsfoundincomplexeswithcadherincelladhesionmoleculesofanimalcells.Thefirsttwocateninsthatwereidentifiedbecameknownasα-cateninandβ-catenin.α-Catenincanbindtoβ-cateninandcanalsobindactin.β-cateninbindsthecytoplasmicdomainofsomecadherins.Whenβ-cateninwassequenceditwasfoundtobeamemberofthearmADIllofamilyofproteins.Theseproteinshavemultiplecopiesoftheso-calledarmadillorepeatdomainwhichisspecializedforprotein-proteinbinding.Anincreaseinβ-cateninproductionhasbeennotedinthosepeoplewhohaveBasalCellCarcinomaandleadstotheincreaseinproliferationofrelatedtumors.Whenβ-cateninisnotassociatedwithcadherinsandα-catenin,itcaninteractwithotherproteinssuchasCateninBetaInteractingProtein1(ICAT)andadenomatosispolyposiscoli(APC).Recentevidencesuggeststhatβ-cateninplaysanimportantroleinvariousaspectsofliverBIOLOGyincludingliverdevelopment(bothembryonicandpostnatal),liverregenerationfollowingpartialhepatectomy,HGF-inducedhepatomegaly,liverzonation,andpathogenesisoflivercancer.
      ProductInformation
      FormatPhycoerythrin
      Control
      PresentationPurifiedmousemonoclonalIgG1κconjugatedtoPEinPBSwith0.1%sodiumazideand15mg/mLBSA.
      StorageandShippingInformation
      StorageConditionsMaintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt.
      Applications
      ApplicationThisMilli-MarkAnti-Beta-cateninAntibody,clone7F7.2isvalidatedforuseinFCforthedetectionofBeta-catenin.
      KeyApplications
      • FlowCytometry
      BiologicalInformation
      ImmunogenFulllength,GST-taggedrecombinantbetacatenin.
      Clone7F7.2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityAntibodyrecognizesBeta-catenin.
      IsotypeIgG1κ
      SpeciesReactivity
      • Mouse
      SpeciesReactivityNoteTestedandpassedonMouse.UnconjugatedAbpartnumber04-958alsoreactsagainsthumanandrat.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryBeta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactinCytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM]
      GeneSymbol
      • CTNNB
      • CTNNB1
      • FLJ25606
      • FLJ37923
      • DKFZp686D02253
      PurificationMethodProteinGPurified
      UniProtNumber
      UniProtSummaryFUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.

      SUBUNIT:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andDUPLIN.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1binding(Bysimilarity).InteractswiththePDZdomainofTAX1BP3;thisinteractioninhibitsthetranscriptionalactivityofCTNNB1(Bysimilarity).InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2andMUC1.InteractswithSLC30A9.InteractswithXIRP1(Bysimilarity).

      SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cytoplasm,cytoskeleton.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2andMUC1promotesnucleartranslocation.

      TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon.
      MolecularWeight92kDaObserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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