| Immunogen | SyntheticpeptidecorrespondingtoaminoacidssurroundingthephosphoSer603ofratSynapsinI.Theimmunogensequenceisidenticalinhuman,mouseandXenopus. | 
| Epitope | phosphoSer603 | 
| Host | Rabbit | 
| Specificity | SynapsinI,phosphoSer603.ThisisthesitephosphorylatedbyCalciumcalmodulinkinaseII.Theantibodyrecognizesthe~78kDSynapsinI,phosphoSer603protein.Immunolabelingisblockedbytheimmunogenpeptidebutnobythecorrespondingnon-phosphopeptide. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneisamemberofthesynapsingenefamily.Synapsinsencodeneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinencodedservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsinthisgenemaybeassociatedwithX-linkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. | 
| GeneSymbol | SYN1SYN1aSynapsin-1SYNISYN1b
 | 
| Modifications |  | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P17600#Neuronalphosphoproteinthatcoatssynapticvesicles,bindstotheCytoskeleton,andisbelievedtofunctionintheregulationofneurotransmitterrelease.ThecomplexformedwithNOS1andCAPONproteinsisnecessaryforspecificnitric-oxidfunctionsatapresynapticlevel. SIZE:705aminoacids;74111Da
 SUBUNIT:Homodimer.InteractswithCAPON.FormsaternarycomplexwithNOS1(Bysimilarity).
 SUBCELLULARLOCATION:Celljunction,synapse.
 PTM:Substrateofatleastfourdifferentproteinkinases.Itisprobablethatphosphorylationplaysaroleintheregulationofsynapsin-1inthenerveterminal.PhosphorylateduponDNAdamage,probablybyATMorATR.
 DISEASE:SwissProt:P17600#DefectsinSYN1areacauseofX-linkedrecessiveepilepsyassociatedwithvariablelearningdisABIlitiesandbehaviordisorders[MIM:300491].
 SIMILARITY:SwissProt:P17600##Belongstothesynapsinfamily.
 |