Millipore/AB1922 | Anti-Integrin β4 Antibody/AB1922/100 µL

價格: ￥4068.00 市場價: 6780.00

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貨號: AB1922

品牌: Millipore

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Description
CatalogueNumber	AB1922
BrandFamily	Chemicon®
TradeName	Chemicon
Description	Anti-Integrinβ4Antibody
AlternateNames	CD104

ProductInformation
Format	Serum
Presentation	Wholerabbitserum.Liquid,with0.02%sodiumazide.

StorageandShippingInformation
StorageConditions	Theundilutedantibodysolutionisstableforapproximately6monthswhenstored-20°C.

Applications
Application	Anti-Integrinβ4AntibodyisanantibodyagainstIntegrinβ4foruseinIP,IH.
KeyApplications	Immunoprecipitation Immunohistochemistry
ApplicationNotes	Immunoprecipitationfromlabeledcellextracts:5μLofserumissufficienttoprecipitatealpha6beta4from1-2x10E6cells.Insomecasesimmunoprecipitationfrom35Smethioninelabeledcellsresultsintwobandsof95and55kDaofunknownorigininadditiontothe200kDaand140kDabandscorrespondingtobeta4andalpha6. Immunohistochemistry:5μg/mL.Seeprotocolbelow. Optimalworkingdilutionsmustbedeterminedbytheenduser. SuggestedProtocolforImmunohistochemical: 1.Fixcryostatsectionswitha1:1chloroform-acetonemixturefor10minutesatroomtemperature. 2.AirDry. 3.Washwith2mLof1xPBS. 4.Add200μLoffirstantibody(5μg/mL)toeachslide.Incubatefor1houratroomtemperatureinahumiditychamber. 5.Washwith5mLof1xPBS. 6.Addappropriatelydilutedanti-rabbitsecondaryantibodyconjugateandincubatefor1hourinahumiditychamber 7.Washwith5mLof1xPBS. 8.Add200μLofdevelopmentsolution(containingDABorothersubstratedependingonthesecondaryantibody)andincubateatroomtemperatureforthenecessarytimetodevelopthedarkcolor.Followthereactionwithamicroscope,toestablishthecorrectcolorintensity. 9.Blockthereactionbywashingwith2mLof1xPBS. 10.Counterstainwithhematoxylinasdesired.

BIOLOGicalInformation
Immunogen	SyntheticpeptidederivedfromtheCOOHterminalsequence(cytoplasmicdomain)ofthehumanβ4integrinsubunit(Tamuraetal.1990).ThesequenceusedisNH2-(K)GTLSTHMDQQFFQT-amide.Thelysine(K)isnotintheβ4sequenceandwasaddedtoconjugatethepeptid
Host	Rabbit
Specificity	Specificforbeta4integrinasdeterminedbyimmunoprecipitation.Theepitoperecognizedisonthecytoplasmicdomainoftheproteinandisthusintracellular.Nocross-reactivitytootherintegrinbsubunits.
SpeciesReactivity	Human Mouse Rat
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_000213.3 NM_001005619.1 NM_001005731.1
EntrezGeneSummary	Integrinsareheterodimerscomprisedofalphaandbetasubunits,thatarenoncovalentlyassociatedtransmembraneglycoproteinreceptors.Differentcombinationsofalphaandbetapolypeptidesformcomplexesthatvaryintheirligand-bindingspecificities.Integrinsmediatecell-matrixorcell-celladhesion,andtransducedsignalsthatregulategeneexpressionandcellgrowth.Thisgeneencodestheintegrinbeta4subunit,areceptorforthelaminins.Thissubunittendstoassociatewithalpha6subunitandislikelytoplayapivotalroleinthebiologyofinvasivecarcinoma.Mutationsinthisgeneareassociatedwithepidermolysisbullosawithpyloricatresia.Multiplealternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene.
GeneSymbol	ITGB4 CD104 GP150
UniProtNumber	P16144
UniProtSummary	FUNCTION:SwissProt:P16144#Integrinalpha-6/beta-4isareceptorforlaminin.Itplaysacriticalstructuralroleinthehemidesmosomeofepithelialcells. SIZE:1822aminoacids;202151Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Beta-4associateswithalpha-6. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Integrinalpha-6/beta-4ispredominantlyexpressedbyepithelia.Isoformbeta-4Disalsoexpressedincolonandplacenta.Isoformbeta-4Eisalsoexpressedinepidermis,lung,duodenum,heart,spleenandstomach. DOMAIN:SwissProt:P16144Thefibronectintype-III-likedomainsbindBPAG1andplectinandprobablyalsorecruitBP230. DISEASE:SwissProt:P16144#DefectsinITGB4areacauseofepidermolysisbullosaletaliswithpyloricatresia(EB-PA)[MIM:226730];alsoknownasjunctionalepidermolysisbullosawithpyloricatresia(PA-JEB)oraplasiacutiscongenitawithgastrointestinalatresia.EB-PAischaracterizedbymucocutaneousfragilityandgastrointestinalatresia,whichmostcommonlyaffectsthepylorus.&DefectsinITGB4areacauseofgeneralizedatrophicbenignepidermolysisbullosa(GABEB)[MIM:226650].Thisnonlethalformofjunctionalepidermolysisbullosaischaracterizedbylife-longblisteringoftheskin,associatedwithhairandtoothabnormalities. SIMILARITY:Belongstotheintegrinbetachainfamily.&Contains1Calx-betadomain.&Contains4fibronectintype-IIIdomains.&Contains1VWFAdomain.

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