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Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL
  • Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL

Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL

價格: ￥4680.00 市場價: 7800.00
貨號: 07-937
品牌: Millipore
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    • Description
      CatalogueNumber07-937
      DescriptionAnti-HDAC7Antibody
      AlternateNames
      • histonedeacetylase7
      • histonedeacetylase7A
      BackgroundInformationHistonedeacetylases(HDAC)areenzymesthatregulatestranscriptionbyselectivelydeacetylatingtheeta-aminogroupsoflysineslocatedneartheaminoterminiofcorehistoneproteins.EightmembersoftheHDACfamilyhavebeenidentified,dividedintotwoclasses.ClassIincludesHDAC-1,2,3and8whileClassIIincludesHDAC-4,5,6,and7.HumanHDAC7iscomposedof912aminoacidresidues.AlthoughHDAC7islocalizedmostlytothecellnucleus,itisalsofoundinthecytoplasm,suggestingnucleo-cytoplasmicshuttling.ThehistonedeacetylaseactivityofHDAC7mapstoaC-terminaldomainandisdependentoninteractionwithclassIHDACsinthenucleus.Itisanactivecomponentofdifferenttranscriptionalco-repressorcomplexesthatcanberecruitedtospecificpromoterregionsviainteractionswithtranscriptionfactors.HDAC7catalyzesremovalofacetyl-groupsfromacetyl-lysinesofhistones,resultinginatighterDNA-histoneinteraction.ThiscompactionofchromatinleadstotherepressionoftranscriptionofDNAinthatregion.
      ProductInformation
      FormatAffinityPurified
      Control
      • RecombinantHDAC7protein(Cat.#14-832).
      PresentationPurifiedRabbitpolyclonalinbuffercontaining20mMPBSand0.1%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8oCfromdateofreceipt.
      Applications
      ApplicationUseAnti-HDAC7Antibody(RabbitPolyclonalAntibody)validatedinWBtodetectHDAC7alsoknownashistonedeacetylase7,histonedeacetylase7A.
      KeyApplications
      • WesternBlotting
      ApplicationNotesWesternBlotting:
      ApreviouslotofthisantibodywasshowntorecognizerecombinantHDAC7butnotrecombinantHDAC1,HDAC4,orHDAC8.

      WesternBlotting:
      ApreviouslotofthisantibodywasshowntorecognizeendogenousHDAC7inHEK293Tcells.
      BIOLOGicalInformation
      ImmunogenSyntheticpeptidecorrespondingtoaminoacids164-182ofhumanHDAC7[(C)KPKKSLERRKNPLLRKESA].
      Epitopea.a.164-182
      HostRabbit
      SpecificityThisantibodyrecognizeshumanHDAC7.Doesnotcross-reactwithHDAC1,HDAC4,orHDAC8.
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteReactswithHuman.Nottestedwithotherspecies.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenehassequencehomologytomembersofthehistonedeacetylasefamily.ThisgeneisorthologoustomouseHDAC7genewhoseproteinpromotesrepressionmediatedviathetranscriptionalcorepressorSMRT.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq].
      GeneSymbol
      • DKFZP586J0917
      • EC3.5.1.98
      • FLJ99588
      • HD7
      • HD7A
      • HD7a
      • HDAC7A
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerfactorssuchasMEF2A,MEF2BandMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactorsBysimilarity.MaybeinvolvedinEpstein-Barrvirus(EBV)latency,possiblybyrepressingtheviralBZLF1gene.

      CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone.

      SUBUNIT:InteractswithHDAC1,HDAC2,HDAC3,HDAC4,HDAC5,NCOR1,NCOR2,SIN3A,SIN3B,RBBP4,RBBP7,MTA1L1,SAP30andMBD3.Interactswiththe14-3-3proteinYWHAE,MEF2A,MEF2BandMEF2CBysimilarity.InteractswithHTATIPandEDNRA.InteractswithJARID1B.

      SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Inthenucleus,itassociateswithdistinctsubnucleardot-likestructures.Shuttlesbetweenthenucleusandthecytoplasm.TreatmentwithEDN1resultsinshuttlingfromthenucleustotheperinuclearregion.Theexporttocytoplasmdependsontheinteractionwiththe14-3-3proteinYWHAEandmaybeduetoitsphosphorylation.

      DOMAIN:ThenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasmBysimilarity.

      PTM:MaybephosphorylatedbyCaMK1Bysimilarity.

      MISCELLANEOUS:ItsactivityisinhibitedbyTrichostatinA(TSA),aknownhistonedeacetylaseinhibitorBysimilarity.

      SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily.

      MolecularWeight100kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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