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Millipore/06-866 | Anti-acetyl-Histone H4 Antibody/06-866/200 µL
  • Millipore/06-866 | Anti-acetyl-Histone H4 Antibody/06-866/200 µL

Millipore/06-866 | Anti-acetyl-Histone H4 Antibody/06-866/200 µL

價格: ￥5304.00 市場價: 8840.00
貨號: 06-866
品牌: Millipore
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    • Description
      CatalogueNumber06-866
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-acetyl-HistoneH4Antibody
      AlternateNames
      • H4histonefamily,memberA
      • histone1
      • H4a
      • histonecluster1
      • H4a
      BackgroundInformationHistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.AcetylationofhistoneH4occursatseveraldifferentlysinepositionsinthehistonetailandisperformedbyafamilyofenzymesknownasHistoneAcetylTransferases(HATs).
      ProductInformation
      FormatSerum
      Control
      • TSA-treatedJurkatcells.Foranegativecontrol,performano-antibodyimmunoprecipitationbyincubatingthesupernatantfractionwith60μlofSalmonSpermDNA/ProteinAAgarose-50%Slurry.TranscriptionallyunactivatedDNAsamplesshouldbepreparedascontrolsforPCR.
      PresentationWholeantiserumcontaining0.05%sodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationUseAnti-acetyl-HistoneH4Antibody(RabbitPolyclonalAntibody)hasbeenpublishedandvalidatedinChIP,WB,ICCtodetectacetyl-HistoneH4alsoknownasH4histonefamilymemberA,histone1-H4a.
      KeyApplications
      • WesternBlotting
      • Immunocytochemistry
      • ChromatinImmunoprecipitation(ChIP)
      ApplicationNotesChromatinImmunoprecipitation:
      5-10μLofthislotimmunoprecipitatedtranscriptionallyactivechromatincontainingacetylatedhistoneH4from2X106serumstimulatedHeLacells.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedpeptidecorrespondingtoa.a.2-19ofTetrahymenahistoneH4[AGGAcKGGAcKGMGAcKVGAAcKRHS-C],acetylatedonlysines5,8,12and16.
      Epitopea.a.2-19
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityAcetylatedhistoneH4,acetylatedhistoneH2BfromTetrahymenaandweaklycross-reactswithacetylatedhistoneH2BfromHeLacells,maycross-reactwithotheracetylatedproteins.
      IsotypeIgG
      SpeciesReactivity
      • Human
      • Tetrahymena
      • Eukaryote
      SpeciesReactivityNoteHumanandTetrahymena.Otherspeciesnottested,butexpectedtocross-reactsinceHistoneH4iswellconserved.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
      GeneSymbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • IST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • 4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      Modifications
      • Acetylation
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.
      SIZE:103aminoacids;11367Da
      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.
      SUBCELLULARLOCATION:Nucleus.
      PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.
      SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family.
      MolecularWeight10kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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